Transforming growth factor-beta (TGFβ) signaling is a complex and highly regulated pathway that plays a critical role in various physiological processes, including cell growth, differentiation, immune response, and tissue repair. Dysregulation of TGFβ signaling has been implicated in a range of diseases, including cancer, fibrosis, and autoimmune disorders. Research in this area focuses on understanding the molecular mechanisms underlying TGFβ signaling, identifying potential therapeutic targets for modulating this pathway, and developing novel treatments for diseases associated with aberrant TGFβ signaling.